From NY Mag:
Vulture has learned that Zoe Saldana is in negotiations to star opposite Mark Ruffalo in the J.J. Abrams–produced marital drama Infinitely Polar Bear, for which screenwriter Maya Forbes (Monsters vs. Aliens, The Larry Sanders Show) will make her directing debut. (Shooting is set to begin in September.) Think of the film as the dramatic version of Mr. Mom, albeit one on Abilify. Ruffalo plays a bipolar husband and father who goes off his medication, and then loses both his sanity and job while struggling to hold onto his marriage. Saldana would play his put-upon wife, who, after going back to work, ends up moving out of the house, leaving him with the kids.